Why the study?
Do halothane and isoflurane alter Ca2+ fluxes in isolated canine cardiac sarcoplasmic reticulum?
Population
Isolated canine cardiac sarcoplasmic reticulum (SR) vesicles (junctional and longitudinal SR)
Comparison
Halothane (0.75-2.5%) or isoflurane (2.5-4%) vs Control conditions without anesthetics
Design
Preclinical
Authors
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May contribute to volatile anesthetic myocardial depression; leaves open relevance to intact human hearts.
Do halothane and isoflurane alter Ca2+ fluxes in isolated canine cardiac sarcoplasmic reticulum?
Halothane and isoflurane depress myocardial function by decreasing net Ca2+ accumulation and increasing passive Ca2+ efflux in the cardiac sarcoplasmic reticulum.
Martha J. Frazer (1992) studied this question.
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