Why the study?
Do volatile anesthetics (halothane, enflurane, isoflurane) alter the gating and conductance of the cardiac sarcoplasmic reticulum Ca2+ release channel in porcine left ventricular tissue?
Population
Vesicles enriched in sarcoplasmic reticulum prepared from porcine left ventricular tissue, fused with…
Comparison
Exposure to clinical concentrations of volatile… vs Absence of volatile anesthetics
Design
Preclinical
Authors
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Does not support changes in clinical anesthetic selection; leaves open translation of porcine SR channel effects to human myocardium.
Do volatile anesthetics (halothane, enflurane, isoflurane) alter the gating and conductance of the cardiac sarcoplasmic reticulum Ca2+ release channel in porcine left ventricular tissue?
Halothane and enflurane, but not isoflurane, activate the cardiac SR Ca2+ release channel, providing a molecular mechanism for their greater negative inotropic effects compared to isoflurane.
Connelly et al. (1994) studied this question.
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