Key result
Halothane, isoflurane, and enflurane completely inhibited Na+/Ca2+ exchange and Ca2+ channels in isolated rat heart cells at concentrations relevant to anesthesia.
Population
Isolated adult rat heart cells in suspension
Design
Preclinical
Authors
Loading...
May inform mechanisms of anesthetic myocardial depression in research models; leaves open in vivo relevance and translation to humans.
Halothane, isoflurane, and enflurane inhibit both Na+/Ca2+ exchange and Ca2+ channels in isolated rat heart cells, which likely contributes to their negative inotropic effects.
Haworth et al. (1995) studied this question. Volatile anesthetics (halothane, isoflurane, and enflurane) was evaluated on Na+/Ca2+ exchange and Ca2+ channel activity. Halothane, isoflurane, and enflurane completely inhibited Na+/Ca2+ exchange and Ca2+ channels in isolated rat heart cells at concentrations relevant to anesthesia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: