February 1, 1994AnesthesiologyOpen Access

Volatile Anesthetic Effects on Sarcoplasmic Reticulum Ca Content and Sarcolemmal Ca Flux in Isolated Rat Cardiac Cell Suspensions

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Population

Isolated quiescent rat cardiac cell suspensions

Comparison

Volatile anesthetics vs Comparison among the three agents and baseline

Design

Preclinical

Authors

DWDavid WheelerDakota State University AKAna KatzSoroka Medical Center RRRalph RiceMissouri State University

Discussion

Member takes

Implication

Should not yet change anesthetic selection; hypothesis-generating for differential Ca handling in human myocardium.

Structured PICO

Population

Isolated quiescent rat cardiac cell suspensions

Intervention

Volatile anesthetics (halothane 1.7 vol% or 0.50 mM, enflurane 4.3 vol% or 1.25 mM, and isoflurane 2.6 vol% or 0.57 mM)

Comparator

Comparison among the three agents and baseline

Outcome

Sarcoplasmic reticulum (SR) Ca content (measured by quin2Ca fluorescence response to caffeine) and net Ca influx across the sarcolemma during sustained depolarizationssurrogate

Volatile anesthetics exert differential effects on sarcoplasmic reticulum calcium content and sarcolemmal calcium influx in isolated rat cardiac cells, with isoflurane uniquely preserving SR calcium content.

Cite This Study

Wheeler et al. (1994) studied this question.

synapsesocial.com/papers/6a82ddce05d1904480d111f4 https://doi.org/10.1097/00000542-199402000-00017

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Volatile Anesthetic Effects on Sarcoplasmic Reticulum Ca Content and Sarcolemmal Ca Flux in Isolated Rat Cardiac Cell Suspensions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Volatile Anesthetic Effects on Sarcoplasmic Reticulum Ca Content and Sarcolemmal Ca Flux in Isolated Rat Cardiac Cell Suspensions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider