Why the study?
Do halothane, enflurane, and isoflurane affect myocardial relaxation in isolated ferret ventricular myocardium?
Population
Papillary muscles of the right ventricle of adult male ferrets (n=27 muscles)
Comparison
Halothane, enflurane, and isoflurane at… vs Baseline and recovery
Design
Preclinical
Authors
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May impair load-dependent relaxation in isolated myocardium; leaves open relevance to human ventricular function during anesthesia.
Do halothane, enflurane, and isoflurane affect myocardial relaxation in isolated ferret ventricular myocardium?
Halothane, enflurane, and isoflurane reversibly decrease load sensitivity of myocardial relaxation in isolated ferret myocardium, suggesting impaired calcium uptake and decreased calcium sensitivity.
Housmans et al. (1988) studied this question.
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