Why the study?
What are the risk factors for excessive anticoagulation (INR > 5) in hospitalized adults receiving warfarin therapy using a pharmacist-managed dosing protocol?
What are the risk factors for excessive anticoagulation (INR > 5) in hospitalized adults receiving warfarin therapy using a pharmacist-managed dosing protocol?
High disease severity, poor nutritional status, interacting drugs, and diarrheal illness significantly increase the risk of excessive anticoagulation in hospitalized patients on warfarin, even with a pharmacist-managed protocol.
These factors may warrant closer INR monitoring in hospitalized warfarin patients; hypothesis-generating for prospective risk-stratification trials.
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Berg et al. (2013) studied this question.
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