What does this research mean for the field?

Coronary spasm or dynamic coronary obstruction is likely involved in the pathogenesis of acute myocardial infarction in patients with spontaneous recanalization or subtotal occlusion, as evidenced by increased coronary vasomotor tone and a higher incidence of pre-infarction angina. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1997Japanese Circulation JournalOpen Access

Increased Coronary Vasomotor Tone in Acute Myocardial Infarction Patients With Spontaneous Coronary Recanalization

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Population

296 Japanese patients with acute myocardial infarction admitted within 24 hours after the onset of chest…

Design

Cohort

Authors

HAHiroyuki AkiyamaMuseum of Nature and Human Activities Hyogo KLKinji lshikawaKindai University KKKen KanamasaCedars-Sinai Medical Center

Discussion

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Implication

May indicate spasm role in select AMI; hypothesis-generating and should not yet alter practice or trials.

Structured PICO

Population

296 Japanese patients with acute myocardial infarction (AMI) admitted within 24 hours after the onset of chest pain. Divided into 3 groups based on initial angiographic findings in the infarct-related coronary artery: group 1 (total occlusion/TIMI 0, n=172), group 2 (subtotal occlusion/TIMI 1-2, n=57), and group 3 (spontaneous recanalization/TIMI 3, n=67).

Outcome

Vasodilation of the proximal normal segment adjacent to the stenotic site of the infarct-related coronary artery induced by intracoronary nitroglycerin, and incidence of pre-infarction angina and intermittent chest pain.surrogate

Patients with AMI and spontaneous recanalization or subtotal occlusion exhibit increased coronary vasomotor tone and higher rates of pre-infarction angina, suggesting coronary spasm plays a role in the pathogenesis of AMI in this population.

Cite This Study

Akiyama et al. (1997) studied this question.

synapsesocial.com/papers/6a1bc37901af05bf0da8eb7d https://doi.org/10.1253/jcj.61.503

Topics

Coronary CT angiography

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Increased Coronary Vasomotor Tone in Acute Myocardial Infarction Patients With Spontaneous Coronary Recanalization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Increased Coronary Vasomotor Tone in Acute Myocardial Infarction Patients With Spontaneous Coronary Recanalization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider