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February 9, 2012Coronary Artery Disease

High incidence of provoked coronary spasm in the presence of a stent after myocardial infarction

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Key result

Provoked coronary spasm after AMI stenting shows no association with major cardiac events.

  • P=0.314
  • n=57

Why the study?

The relationship between coronary spasm and stent implantation after AMI and its clinical implications remain unknown.

What is the incidence and clinical implication of provoked coronary spasm after stent implantation in patients with AMI?

Population

57 patients with ST elevation AMI after stent implantation

Comparison

Patients with provoked coronary spasm vs patients without provoked coronary spasm

Design

Cohort study with provocation test for coronary spasm

Follow-up

Average 35.0±26.9 months

Authors

DKDaisuke KatohBeth Israel Deaconess Medical CenterYMYuji MizunoHeart Failure / CardiomyopathyEHEisaku HaradaTotal (France)

Discussion

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Implication

Provoked spasm common after AMI stenting yet unlinked to events; leaves open whether routine testing or calcium channel blockers alter prognosis.

Study Design

Type

Cohort (n=57)

Structured PICO

What is the incidence and clinical implication of provoked coronary spasm after stent implantation in patients with AMI?

P
Population
57 patients (mean age 65.1 years, 24.6% female) with ST elevation AMI who had undergone stent implantation, followed for an average of 35.0 months.
E
Exposure
Provocation test for coronary spasm by intracoronary injection of acetylcholine 2-5 weeks after AMI, followed by calcium channel blockers for patients with provoked spasms.
C
Comparator
Patients without provoked coronary spasm.
O
Outcome
Incidence of provoked coronary spasm and major cardiac events during follow-up.hard clinical

Main Result

p-value: p=0.314

Coronary spasm is frequently provoked after stent implantation in AMI patients, and treatment with calcium channel blockers in these patients may result in similar clinical outcomes to those without spasm.

Cite This Study

Katoh et al. (2012) conducted a cohort in ST elevation acute myocardial infarction (AMI) (n=57). Provoked coronary spasm vs. No provoked coronary spasm was evaluated on Major cardiac events (p=0.314). Provoked coronary spasm occurred in 70.2% of patients after stent implantation for AMI, with no significant difference in major cardiac events between the spasm and nonspasm groups (P=0.314).

synapsesocial.com/papers/6aa8f4267c2f2078012c7e33https://doi.org/10.1097/mca.0b013e32835115ee
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary artery spasm associated with variant angina pectoris.1974 · 45 citations
  2. 2Angiographic and Pathologic Correlations in Prinzmetal Variant Angina1978 · 12 citations
  3. 3Prinzmetal's variant form of angina pectoris. Re-evaluation of mechanisms.1975 · 189 citations
  4. 4Prinzmetal Variant of Angina Pectoris1974 · 4 citations