What does this research mean for the field?

Transdiaphragmatic twitch pressure measurements accurately assess diaphragmatic low- and high-frequency fatigue and quantify the intensity of central drive to the diaphragm, remaining valid despite twitch potentiation or lack of thoracoabdominal binding. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1994Journal of Applied Physiology

Use of twitch pressures to assess diaphragmatic function and central drive

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Population

Rabbit model of diaphragmatic contractile dysfunction and diaphragmatic fatigue

Comparison

Diaphragmatic twitch and twitch occlusion… vs Phrenic nerve recordings and low-/high-frequency…

Design

Preclinical

Authors

GFGary T. FergusonSt. Mary’s Health Care System

Discussion

Member takes

Implication

Supports twitch-based diaphragmatic monitoring in preclinical models; leaves open translation to clinical central drive assessment.

Structured PICO

Population

Rabbit model of diaphragmatic contractile dysfunction and diaphragmatic fatigue

Intervention

Diaphragmatic twitch and twitch occlusion measurements (single-twitch, 20-Hz double- and triple-twitch, 80-Hz triple-twitch)

Comparator

Phrenic nerve recordings and low-/high-frequency diaphragm trains

Outcome

Accuracy of diaphragmatic twitch pressures to assess changes in low- and high-frequency diaphragm trains during fatigue and recovery, and accuracy of twitch occlusion measurements to quantify central drive intensitysurrogate

Twitch measurements can accurately assess diaphragmatic low- and high-frequency fatigue and quantify the intensity of central drive to the diaphragm in a rabbit model.

Cite This Study

Gary T. Ferguson (1994) studied this question.

synapsesocial.com/papers/6a1bc4f2fc87fd06169ccefe https://doi.org/10.1152/jappl.1994.77.4.1705

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Use of twitch pressures to assess diaphragmatic function and central drive

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Use of twitch pressures to assess diaphragmatic function and central drive

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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