What does this research mean for the field?

Increased monocyte expression of adiponectin receptors (AdipoR1 and AdipoR2) is independently associated with increased aortic stiffness, carotid intima-media thickness, and the extent of coronary atherosclerosis in patients with coronary artery disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 26, 2012American Journal of HypertensionOpen Access

Arterial Stiffness Is Associated With Increased Monocyte Expression of Adiponectin Receptor mRNA and Protein in Patients With Coronary Artery Disease

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Population

71 patients (61 men, 10 women) with angiographically proven coronary artery disease (CAD)

Design

Cross-sectional

Authors

IIIgnatios IkonomidisPreventive Cardiology NKNikolaos P. E. KadoglouHeart Failure & Transplant PTPanayoula C. TsiotraHellenic Center for Disease Control & Prevention

Discussion

Member takes

Implication

Monocyte AdipoR expression may mark aortic stiffness in CAD; hypothesis-generating and requires prospective validation before clinical adoption.

Structured PICO

Population

71 patients (61 men, 10 women) with angiographically proven coronary artery disease (CAD)

Outcome

Association of AdipoR1 and AdipoR2 mRNA and protein expression with arterial stiffness (pulse wave velocity), carotid IMT, and extent of coronary atherosclerosissurrogate

Increased monocyte expression of adiponectin receptors is independently associated with increased aortic stiffness and atherosclerosis in patients with coronary artery disease.

Cite This Study

Ikonomidis et al. (2012) studied this question.

synapsesocial.com/papers/6a1bc52cc97d63156a5ee80b https://doi.org/10.1038/ajh.2012.42

Topics

Coronary artery disease

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Implication

Monocyte AdipoR expression may mark aortic stiffness in CAD; hypothesis-generating and requires prospective validation before clinical adoption.