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May 1, 2002Cardiovascular Research

Suppression of atrial fibrillation by multisite and septal pacing in a novel experimental model

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Why the study?

Does multisite and septal pacing reduce the number and duration of AF episodes in a canine model of atrial fibrillation?

Population

12 foxhounds with induced sterile right atrial pericarditis and simulated atrial extrasystoles

Comparison

Preventive multisite and septal pacing at a… vs Single-site high right atrial (HRA) pacing

Design

Preclinical, order randomized

Follow-up

10 min intervals

Authors

RBRuediger BeckerHeidelberg University

Discussion

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Implication

Hypothesis-generating for multisite pacing in paroxysmal AF models; should not yet change clinical practice.

Structured PICO

Does multisite and septal pacing reduce the number and duration of AF episodes in a canine model of atrial fibrillation?

P
Population
12 foxhounds with induced sterile right atrial pericarditis (anatomical substrate for AF) and simulated atrial extrasystoles
I
Intervention
Preventive multisite and septal pacing (HRA, septal, HRA+LRA, HRA+LLA, HRA+LRA+LLA, HRA+LRA+HLA+LLA) at a cycle length 30 ms below sinus rate
C
Comparator
Single-site high right atrial (HRA) pacing
O
Outcome
Number and duration of AF episodes during 10 min intervalssurrogate

Quadruple-site and single-site septal pacing effectively suppress paroxysmal AF in a novel experimental canine model.

Cite This Study

Ruediger Becker (2002) studied this question.

synapsesocial.com/papers/6a1bc58100ee29383e9cdde6https://doi.org/10.1016/s0008-6363(02)00231-6

Topics

Atrial fibrillationPersistent AF managementPericardial diseaseAF ablation outcomesAnticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of Atrial Fibrillation in Man: Studies Following Open Heart Surgery*1978 · 293 citations
  2. 2No incremental benefit of multisite atrial pacing compared with right atrial pacing in patients with drug refractory paroxysmal atrial fibrillation2001 · 44 citations
  3. 3Long‐Term Effects of Biatrial Synchronous Pacing to Prevent Drug‐Refractory Atrial Tachyarrhythmia: A Nine‐Year Experience2000 · 127 citations
  4. 4Intra-atrial reentry as a mechanism for atrial flutter induced by acetylcholine and rapid pacing in the dog.1984 · 279 citations
  5. 5Circus movement atrial flutter in the canine sterile pericarditis model. Activation patterns during initiation, termination, and sustained reentry in vivo.1990 · 64 citations