Why the study?
Does a single oral dose of disopyramide alter systolic and early diastolic time intervals in patients with hypertrophic cardiomyopathy?
Population
26 patients with hypertrophic cardiomyopathy (5 obstructive type: HOCM, 21 non-obstructive type: HNCM)
Comparison
Disopyramide 100 mg single oral administration vs Baseline (at rest before administration)
Design
Cohort
Follow-up
3 hours
Authors
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May indicate hemodynamic effects in HCM; hypothesis-generating and requires randomized confirmation before practice change.
Does a single oral dose of disopyramide alter systolic and early diastolic time intervals in patients with hypertrophic cardiomyopathy?
A single oral dose of disopyramide alters systolic and early diastolic time intervals in patients with hypertrophic cardiomyopathy, suggesting decreased pressure gradient in HOCM, decreased myocardial contractility, and improved left-ventricular filling.
Sumimoto et al. (1991) studied this question.
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