What does this research mean for the field?

Labetalol exhibits significant antiarrhythmic activity against arrhythmias induced by programmed electrical stimulation following myocardial infarction, likely due to its adrenoceptor blocking properties combined with class I and III electrophysiological activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1990British Journal of PharmacologyOpen Access

Antiarrhythmic efficacy of labetalol as assessed by programmed electrical stimulation

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Why the study?

Does labetalol prevent arrhythmias induced by programmed electrical stimulation in conscious dogs after myocardial infarction?

Population

Conscious dogs in the late reperfusion phase after myocardial infarction

Comparison

Labetalol in cumulative doses vs Control

Design

Preclinical

Authors

GKGünther KrumplInternational Academy of Philosophy HTHannes TodtUniversity of Vienna KKKurt KrejcyAOP Orphan (Austria)

Discussion

Member takes

Implication

Supports antiarrhythmic activity in post-MI canine models; hypothesis-generating and leaves open human translation.

Structured PICO

Does labetalol prevent arrhythmias induced by programmed electrical stimulation in conscious dogs after myocardial infarction?

Population

Conscious dogs in the late reperfusion phase after myocardial infarction

Intervention

Labetalol in cumulative doses (0.5, 1 and 3 mg kg-1 90 min-1, i.v.)

Comparator

Control

Outcome

Antiarrhythmic efficacy against arrhythmias induced by programmed electrical stimulationsurrogate

Labetalol exhibits antiarrhythmic efficacy against induced arrhythmias in a canine model of post-myocardial infarction reperfusion.

Cite This Study

Krumpl et al. (1990) studied this question.

synapsesocial.com/papers/6a1bc643bc71fb1015a8f381 https://doi.org/10.1111/j.1476-5381.1990.tb14104.x

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Antiarrhythmic efficacy of labetalol as assessed by programmed electrical stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antiarrhythmic efficacy of labetalol as assessed by programmed electrical stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider