Why the study?
Does UK 52,046-27 reduce the incidence of arrhythmias and alter cellular electrophysiology during ischaemia and reperfusion in isolated guinea-pig hearts?
Does UK 52,046-27 reduce the incidence of arrhythmias and alter cellular electrophysiology during ischaemia and reperfusion in isolated guinea-pig hearts?
Blockade of the alpha 1-adrenoceptor subpopulation with UK 52,046-27 decreases the incidence of arrhythmias and alters cellular electrophysiology during myocardial ischaemia and reperfusion in a guinea-pig model.
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Supports alpha1-blockade for ischemia-reperfusion arrhythmias; extends animal data but leaves clinical translation open.
Flores et al. (1989) studied this question.
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