Why the study?
Does UK-66,914 alter conduction velocity or prevent ventricular tachycardias in canine hearts with chronic myocardial infarction?
Population
Canine hearts with a previous myocardial infarction
Comparison
UK-66,914 vs d-sotalol and procainamide (in vitro comparison)
Design
Preclinical
Authors
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Supports further preclinical testing of UK-66,914 for post-infarct VT; leaves open translation to clinical use.
Does UK-66,914 alter conduction velocity or prevent ventricular tachycardias in canine hearts with chronic myocardial infarction?
UK-66,914 is a potent Class III antiarrhythmic agent that prolongs the effective refractory period and prevents ventricular tachycardia induction without slowing conduction velocity or depressing contractility in a canine infarct model.
Onufer et al. (1991) studied this question.
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