Why the study?
Do methanesulfonanilide class III antiarrhythmic agents increase myocardial refractoriness compared to d-sotalol in ferret papillary muscle preparations?
Do methanesulfonanilide class III antiarrhythmic agents increase myocardial refractoriness compared to d-sotalol in ferret papillary muscle preparations?
New methanesulfonanilide class III antiarrhythmic agents are significantly more potent than d-sotalol in increasing ventricular effective refractory period in ferret papillary muscles, with effects attenuated by faster pacing and hypoxia.
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May support preclinical development of potent class III agents; leaves open translation to human arrhythmia management.
Baskin et al. (1991) studied this question.
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