Why the study?
Does NE-10064 prolong action potential duration and effective refractory period compared to sotalol and E-4031 in sheep Purkinje fibres?
Population
Sheep Purkinje fibres paced at 1 Hz under normal and simulated ischaemic conditions
Comparison
NE-10064 0.3-3 microM vs Sotalol 0.3-300 microM and E-4031 0.3-300 microM
Design
Preclinical
Authors
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Attenuated APD effects under ischaemia suggest context-specific class III activity; leaves open translation to human arrhythmia models.
Does NE-10064 prolong action potential duration and effective refractory period compared to sotalol and E-4031 in sheep Purkinje fibres?
NE-10064 demonstrates class III anti-arrhythmic electrophysiologic characteristics in sheep Purkinje fibres, which are attenuated under simulated ischaemic conditions.
McIntosh et al. (1994) studied this question.
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