Why the study?
Does NE-10064 reduce PES-induced VT and ischemia-induced VF in a canine model of sudden cardiac death?
Population
Purpose bred male mongrel dogs weighing 14.5-21.5 kg with surgical anterior myocardial infarction induced by…
Comparison
NE-10064 10 mg/kg intravenously vs Vehicle (5% dextrose in water) or predrug baseline
Design
Preclinical
Follow-up
14 hours
Authors
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NE-10064 merits further preclinical arrhythmia testing; leaves open translation to human sudden cardiac death prevention.
Does NE-10064 reduce PES-induced VT and ischemia-induced VF in a canine model of sudden cardiac death?
In a canine model of sudden cardiac death, the Class III antiarrhythmic NE-10064 reduced the inducibility of VT and improved survival during ischemia.
Black et al. (1993) studied this question.
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