Key result
In a canine myocardial infarction model, MS-551 abolished or lessened PES-induced ventricular arrhythmias in 7 of 10 animals without significantly affecting hemodynamics.
Why the study?
Does MS-551 suppress programmed electrical stimulation-induced ventricular arrhythmias in a canine myocardial infarction model?
Does MS-551 suppress programmed electrical stimulation-induced ventricular arrhythmias in a canine myocardial infarction model?
MS-551 suppresses PES-induced ventricular arrhythmias by prolonging the effective refractory period without significant hemodynamic effects in a canine MI model.
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Supports antiarrhythmic testing of MS-551 in MI models; leaves open human translation and safety.
Kondoh et al. (1994) studied Myocardial infarction (canine model) (n=12). MS-551 was evaluated on Programmed electrical stimulation (PES)-induced ventricular arrhythmias. In a canine myocardial infarction model, MS-551 abolished or lessened PES-induced ventricular arrhythmias in 7 of 10 animals without significantly affecting hemodynamics.
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