Why the study?
Do new methanesulfonanilide class III antiarrhythmic agents alter cardiac electrophysiologic and hemodynamic parameters compared to D-sotalol in anesthetized dogs?
Do new methanesulfonanilide class III antiarrhythmic agents alter cardiac electrophysiologic and hemodynamic parameters compared to D-sotalol in anesthetized dogs?
Potent and selective methanesulfonanilide class III agents augment cardiac contractility in addition to prolonging ventricular refractoriness in an anesthetized dog model.
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Positive inotropy accompanies refractoriness prolongation with these agents in dogs; leaves open human translation or clinical utility.
Wallace et al. (1991) studied this question.
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