Why the study?
Do dofetilide, D-sotalol, E-4031, and MK-499 increase myocardial effective refractory period in ferret right ventricular papillary muscles under varying potassium concentrations and pacing frequencies?
Do dofetilide, D-sotalol, E-4031, and MK-499 increase myocardial effective refractory period in ferret right ventricular papillary muscles under varying potassium concentrations and pacing frequencies?
The Class III antiarrhythmic agents dofetilide, D-sotalol, E-4031, and MK-499 show diminished ability to prolong refractoriness in conditions of elevated extracellular potassium, though D-sotalol and MK-499 are less affected than dofetilide and E-4031.
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Attenuated ERP prolongation in hyperkalemia cautions against reliance on these agents in ischemia; leaves open comparative advantages of D-sotalol and MK-499.
Baskin et al. (1994) studied this question.
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