What does this research mean for the field?

Phentolamine and several other alpha-adrenoceptor antagonists block the fast sodium channel in cardiac tissue in a concentration- and frequency-dependent manner similar to lignocaine, an effect that is independent of alpha-adrenoceptor blockade. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1983British Journal of PharmacologyOpen Access

A comparison of the electrophysiological actions of phentolamine with those of some other antiarrhythmic drugs on tissues isolated from the rat heart

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Population

Segments from the atrial and right ventricular free walls of rat hearts

Comparison

Phentolamine mesylate and other… vs Baseline/control conditions

Design

Preclinical

Authors

BNB. J. NorthoverLeicester Royal Infirmary

Discussion

Member takes

Implication

Phentolamine's sodium channel blockade in rat hearts is hypothesis-generating; should not inform clinical use without human data.

Structured PICO

Population

Segments from the atrial and right ventricular free walls of rat hearts (including reserpine pretreated and non-pretreated rats)

Intervention

Phentolamine mesylate (2 to 20 microM) and other alpha-adrenoceptor antagonists (prazosin, yohimbine, tolazoline, dihydroergotamine, dibenamine, phenoxybenzamine), lignocaine hydrochloride, and quinidine sulphate

Comparator

Baseline/control conditions (varying KCl and CaCl2 concentrations, varying stimulation frequencies)

Outcome

Transmembrane electrical activity (maximum rate of rise of membrane potential during phase 0, refractory period, recovery of excitability)surrogate

Phentolamine and several other alpha-adrenoceptor antagonists exhibit concentration-dependent fast sodium channel blocking properties in isolated rat heart tissue, similar to lignocaine.

Cite This Study

B. J. Northover (1983) studied this question.

synapsesocial.com/papers/6a1bc643bc71fb1015a8f388 https://doi.org/10.1111/j.1476-5381.1983.tb11053.x

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A comparison of the electrophysiological actions of phentolamine with those of some other antiarrhythmic drugs on tissues isolated from the rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A comparison of the electrophysiological actions of phentolamine with those of some other antiarrhythmic drugs on tissues isolated from the rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider