Why the study?
Does phentolamine act as an agonist on sympathetic nerve endings and blood pressure in rabbit models?
Population
Rabbit isolated right atrium and ganglion-blocked (mecamylamine) conscious or anaesthetized rabbits
Comparison
Phentolamine vs Baseline response; effects of antagonists…
Design
Preclinical
Authors
Loading...
Phentolamine may be unsuitable as alpha-antagonist in rabbit models; leaves open species-specific presynaptic agonist effects for further study.
Does phentolamine act as an agonist on sympathetic nerve endings and blood pressure in rabbit models?
Phentolamine exhibits unexpected alpha 2-adrenoceptor agonist effects in rabbits, making it unsuitable as an alpha-adrenoceptor antagonist in this species.
Angus et al. (1984) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: