What does this research mean for the field?

Lipoprotein (a) concentrations are significantly elevated in children over 10 years of age who have a parent with coronary heart disease, suggesting its utility as an early risk indicator for atherosclerosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1991Archives of Disease in ChildhoodOpen Access

Lipoprotein (a) concentrations as risk indicators for atherosclerosis.

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Why the study?

Are plasma lipoprotein (a) concentrations elevated in children with a parental history of coronary heart disease or cerebrovascular disease compared to controls?

Structured PICO

Are plasma lipoprotein (a) concentrations elevated in children with a parental history of coronary heart disease or cerebrovascular disease compared to controls?

Population

194 children, comprising 102 controls, 42 children with a parent suffering from coronary heart disease (CHD), and 50 children with a parent with cerebrovascular disease (CVD).

Comparator

Control children (n=102)

Outcome

Plasma concentrations of different lipoproteins, including lipoprotein (a), apolipoprotein A I, apolipoprotein B, high density lipoprotein-cholesterol, total cholesterol, and apolipoprotein A II, as well as plasma glycosaminoglycan concentrations.surrogate

Lipoprotein (a) concentrations are significantly elevated in children over 10 years of age with a parental history of coronary heart disease, suggesting its potential role as an early risk indicator for atherosclerosis.

Discussion

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Implication

Lp(a) elevation in children with parental CHD history should not yet change practice; leaves open its value for early risk stratification pending prospective data.

Cite This Study

Kostner et al. (1991) studied this question.

synapsesocial.com/papers/6a1bc8b0ea84844e355ef3b3 https://doi.org/10.1136/adc.66.9.1054

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Implication

Lp(a) elevation in children with parental CHD history should not yet change practice; leaves open its value for early risk stratification pending prospective data.

Lipoprotein (a) concentrations as risk indicators for atherosclerosis.

Structured PICO

Discussion

Implication

Cite This Study

Lipoprotein (a) concentrations as risk indicators for atherosclerosis.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider