What does this research mean for the field?

In middle-aged women, depression is associated with higher insulin resistance and incident diabetes largely due to mediation by central adiposity, except in African-American women where depression independently predicts a 2.56-fold greater risk of diabetes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 2004Diabetes CareOpen Access

Depressive Symptoms, Insulin Resistance, and Risk of Diabetes in Women at Midlife

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Why the study?

Does depression increase insulin resistance and the risk of incident diabetes in middle-aged women?

Population

2,662 Caucasian, African-American, Hispanic, Japanese-American, and Chinese-American middle-aged women…

Comparison

Depression vs No depression

Design

Cohort

Follow-up

3 years

Authors

SESusan A. Everson‐RosePreventive Cardiology PMPeter MeyerIowa State University LPLynda H. PowellGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Depression-diabetes link in midlife women largely mediated by adiposity; leaves independent risk in African Americans open for confirmation.

Structured PICO

Does depression increase insulin resistance and the risk of incident diabetes in middle-aged women?

Population

2,662 Caucasian, African-American, Hispanic, Japanese-American, and Chinese-American middle-aged women without a history of diabetes from the Study of Women's Health Across the Nation

Intervention

Depression (Center for Epidemiological Studies Depression Scale score ≥16)

Comparator

No depression (Center for Epidemiological Studies Depression Scale score <16)

Outcome

3-year change in homeostasis model assessment of insulin resistance (HOMA-IR) and risk of incident diabetes

Depression is associated with higher insulin resistance and incident diabetes in midlife women, largely mediated by central adiposity, except in African-American women where the risk remains independent.

Cite This Study

Everson‐Rose et al. (2004) studied this question.

synapsesocial.com/papers/6a1bc8b86f692abb725ee15b https://doi.org/10.2337/diacare.27.12.2856

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Implication

Depression-diabetes link in midlife women largely mediated by adiposity; leaves independent risk in African Americans open for confirmation.

Depressive Symptoms, Insulin Resistance, and Risk of Diabetes in Women at Midlife

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Depressive Symptoms, Insulin Resistance, and Risk of Diabetes in Women at Midlife

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider