Depressive Symptoms, Insulin Resistance, and Risk of Diabetes in Women at Midlife
Why the study?
Is there an association between depressive symptoms, insulin resistance, and the risk of diabetes in women at midlife?
Population
Women at midlife without overt diabetes at baseline
Authors
Discussion
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Member takes
Implication
Excluding baseline diabetes reduces reverse causation likelihood; leaves open depressive symptoms as a diabetes risk driver in midlife women.
Structured PICO
Is there an association between depressive symptoms, insulin resistance, and the risk of diabetes in women at midlife?
P
Population
Women at midlife without overt diabetes at baseline (fasting blood glucose <126 mg/dl and no self-reported history of diabetes)
I
Intervention
Depressive symptoms and insulin resistance (exposures)
O
Outcome
Risk of diabetes
The authors address comments on their study, noting that baseline overt diabetes was excluded, making it unlikely that insulin resistance causing depression explains their findings.
Cite This Study
Everson‐Rose et al. (2005) studied this question.