Depressive Symptoms and Risk of Type 2 Diabetes in Women
Why the study?
Do depressive symptoms increase the risk of developing type 2 diabetes in middle-aged women?
Population
72,178 female nurses aged 45-72 years without diagnosed diabetes at baseline
Comparison
Presence of depressive symptoms vs Absence of depressive symptoms
Design
Cohort
Follow-up
4 years
Authors
Discussion
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Implication
Depressive symptoms were associated with higher T2D risk in women; hypothesis-generating for bidirectional trials before any practice change.
Key Points
- To investigate the association between depressive symptoms and the incidence of type 2 diabetes in women.
- Prospective cohort analysis of 72,178 female nurses aged 45–72 years without diagnosed diabetes at baseline in 1992.
- Depressive symptoms were assessed using the Five-Item Mental Health Index (MHI-5 score >52) from the SF-36 survey.
- Relative risks (RR) of incident type 2 diabetes were calculated across 4 years of follow-up (282,317 person-years).
- Over 4 years of follow-up, 973 incident cases of type 2 diabetes occurred, with an age-adjusted RR of 1.55 (95% CI 1.27–1.90) for women with depressive symptoms.
- Adjustment for BMI attenuated the RR to 1.36 (95% CI 1.11–1.67), and full multivariate adjustment yielded an RR of 1.22 (95% CI 1.00–1.50).
- Excluding early cases diagnosed between 1992 and 1994 yielded 472 incident cases across 148,889 person-years, with a multivariate RR of 1.29 (95% CI 0.96–1.72).
Structured PICO
Do depressive symptoms increase the risk of developing type 2 diabetes in middle-aged women?
P
Population
72,178 female nurses aged 45-72 years without diagnosed diabetes at baseline
I
Intervention
Presence of depressive symptoms (Five-Item Mental Health Index [MHI-5] score >52)
C
Comparator
Absence of depressive symptoms
O
Outcome
Incidence of type 2 diabeteshard clinical
Depressive symptoms are associated with a modest increase in the risk of developing type 2 diabetes in women.
Cite This Study
Arroyo et al. (2004) studied this question.