Glycemia, Insulin Resistance, Insulin Secretion, and Risk of Depressive Symptoms in Middle Age
Key result
Low insulin secretion in middle-aged women was associated with a significantly increased risk of developing new-onset depressive symptoms over 5 years (OR 2.18; 95% CI 1.25-3.78).
Why the study?
Does low insulin secretion increase the risk of new-onset depressive symptoms in middle-aged adults?
Population
3,145 adults from the Whitehall II Study, aged 60.6 ± 5.9 years, 23.5% women
Comparison
Lowest quintile of insulin secretion and other… vs Higher insulin secretion and other quintiles of…
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Implication
Hypothesis-generating in middle-aged women; prospective studies needed to assess causality and clinical utility before practice change.
Study Design
Type
Cohort (n=3,145)
Structured PICO
Does low insulin secretion increase the risk of new-onset depressive symptoms in middle-aged adults?
P
Population
3,145 adults (23.5% women, mean age 60.6 years) from the Whitehall II Study, followed for 5 years to assess new-onset depressive symptoms.
E
Exposure
Lowest quintile of insulin secretion (HOMA2-%B ≤55.3%) and other indices of glucose metabolism (fasting glucose, fasting insulin, HOMA2-%IR)
C
Comparator
Higher insulin secretion and other quintiles of glucose metabolism indices
O
Outcome
New-onset depressive symptoms (Center for Epidemiologic Studies Depression Scale ≥16 or use of antidepressive drugs) at 5-year follow-uppatient reported
Main Result
Odds Ratio: 2.18 (95% CI 1.25–3.78)
Low insulin secretion is associated with an increased risk of developing depressive symptoms in middle-aged women.
Cite This Study
Akbaraly et al. (2012) conducted a cohort in Depressive symptoms (n=3,145). Low insulin secretion (HOMA2-%B ≤55.3%) vs. Higher insulin secretion was evaluated on New-onset depressive symptoms (DepS) (OR 2.18, 95% CI 1.25-3.78). Low insulin secretion in middle-aged women was associated with a significantly increased risk of developing new-onset depressive symptoms over 5 years (OR 2.18; 95% CI 1.25-3.78).