What question did this study set out to answer?

To prospectively examine the relationship between low baseline levels of testosterone and sex hormone-binding globulin (SHBG) and the subsequent development of type 2 diabetes in middle-aged men.

April 1, 2000Diabetes CareOpen Access

Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.

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Authors

RSRebecca K. StellatoUniversity Medical Center Utrecht HFHenry A. FeldmanBoston Children's Hospital OHOsama HamdyJoslin Diabetes Center

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Implication

Prospective cohort study reveals that low free testosterone and sex hormone-binding globulin predict type 2 diabetes in middle-aged men, suggesting a hormonal role in disease onset.

Key Points

To prospectively examine the relationship between low baseline levels of testosterone and sex hormone-binding globulin (SHBG) and the subsequent development of type 2 diabetes in middle-aged men.
Prospective population-based cohort of 1,709 men aged 40–70 years enrolled at baseline (1987–1989), with 1,156 followed up 7–10 years later.
Baseline testosterone and SHBG concentrations were assessed as prospective predictors of incident type 2 diabetes after adjusting for potential confounders.
Lower baseline free testosterone independently predicted incident diabetes, with an odds ratio of 1.58 (P < 0.02) per 1 SD decrease (4 ng/dl).
Lower baseline SHBG independently predicted incident diabetes, with an odds ratio of 1.89 (P < 0.02) per 1 SD decrease (16 nmol/l).

Cite This Study

Stellato et al. (2000) studied this question.

synapsesocial.com/papers/6a1bc8b86f692abb725ee161 https://doi.org/10.2337/diacare.23.4.490

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Implication

Prospective cohort study reveals that low free testosterone and sex hormone-binding globulin predict type 2 diabetes in middle-aged men, suggesting a hormonal role in disease onset.

Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.

Discussion

Member takes

Implication

Key Points

Cite This Study

Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.

Discussion

Member takes

Implication

Key Points

Cite This Study

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