What question did this study set out to answer?

Assess the clinical safety, infectivity risk, and pathogenicity profiles of probiotic preparations formulated with lactobacilli or bifidobacteria.

March 15, 2003Clinical Infectious DiseasesOpen Access

Safety of Probiotics That Contain Lactobacilli or Bifidobacteria

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Assess the clinical safety, infectivity risk, and pathogenicity profiles of probiotic preparations formulated with lactobacilli or bifidobacteria.
Evaluated incidence rates of clinical infections associated with lactobacilli and bifidobacteria strains in healthy cohorts and immunocompromised populations.
Assessed strain selection guidelines regarding human commensal origin, transmissible antibiotic resistance traits, and reference laboratory surveillance protocols.
Lactobacilli and bifidobacteria demonstrate extremely low pathogenicity, with probiotic-induced infections occurring on exceedingly rare occasions across all age groups and in immunocompromised hosts.
Safe probiotic formulation requires strains derived from human commensal microbiota that do not harbor intrinsic antibiotic resistance capable of impeding medical therapy.
Active surveillance and submission of suspect clinical isolates to reference centers for molecular characterization remain essential for confirming rare probiotic infections.

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Implication

Review finds negligible infection risk from lactobacilli and bifidobacteria probiotics across all populations, highlighting their broad clinical safety.

Cite This Study

Borriello et al. (2003) studied this question.

synapsesocial.com/papers/6a1bc910ea84844e355ef4c5 https://doi.org/10.1086/368080

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Implication

Review finds negligible infection risk from lactobacilli and bifidobacteria probiotics across all populations, highlighting their broad clinical safety.

Safety of Probiotics That Contain Lactobacilli or Bifidobacteria

Key Points

Discussion

Implication

Cite This Study

Safety of Probiotics That Contain Lactobacilli or Bifidobacteria

Key Points

Discussion

Implication

Cite This Study

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