Why the study?
Does forced expression of DGAT1 in cardiac myocytes cause lipid accumulation and heart dysfunction in mice?
Population
Cardiac myocyte-selective DGAT1 transgenic mice
Design
Preclinical
Follow-up
up to 52 weeks
Authors
Loading...
Cardiac lipid accumulation may suffice to cause cardiomyopathy in mice; leaves open human relevance and mechanisms.
Does forced expression of DGAT1 in cardiac myocytes cause lipid accumulation and heart dysfunction in mice?
Isolated cardiac triglyceride accumulation, even without systemic metabolic derangement, is sufficient to cause cardiac dysfunction and decreased mitochondrial biogenesis in a murine model.
Glenn et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: