Why the study?
Does cardiac-specific overexpression of FATP1 cause lipotoxic cardiomyopathy in mice?
Population
Transgenic mice engineered with cardiac-specific overexpression of fatty acid transport protein 1 using the…
Design
Preclinical
Follow-up
3 months of age
Authors
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Cardiac FATP1 overexpression induces lipotoxic diastolic dysfunction in mice; extends mechanistic models but leaves open human HFpEF relevance.
Does cardiac-specific overexpression of FATP1 cause lipotoxic cardiomyopathy in mice?
Perturbation of cardiomyocyte lipid homeostasis via FATP1 overexpression causes lipotoxic cardiomyopathy with diastolic dysfunction, independent of systemic metabolic disturbances.
Chiu et al. (2004) studied this question.
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