Why the study?
Are maternal vasculopathy and poor first-trimester glycemic control associated with major congenital malformations in infants of women with IDDM?
Population
165 first pregnancies of women with insulin-dependent diabetes mellitus (IDDM) from 1978 to 1986.
Comparison
Maternal vasculopathy and poor first-trimester… vs Absence of maternal vasculopathy and adequate…
Design
Cohort
Follow-up
throughout gestation to birth
Authors
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Preexisting vasculopathy and first-trimester hyperglycemia were associated with malformations in IDDM; leaves open whether optimizing these reduces risk.
Are maternal vasculopathy and poor first-trimester glycemic control associated with major congenital malformations in infants of women with IDDM?
Maternal vasculopathy and poor first-trimester glycemic control are independent risk factors for major congenital malformations in infants of women with IDDM.
Miodovnik et al. (1988) studied this question.
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