Why the study?
Abnormal ventricular repolarization, indicated by prolonged Tp-e, is associated with increased sudden death risk, prompting investigation into the effects of tobacco and electronic cigarettes on ECG indexes of repolarization.
Does smoking tobacco or electronic cigarettes with nicotine adversely impact ECG indexes of ventricular repolarization?
Does smoking tobacco or electronic cigarettes with nicotine adversely impact ECG indexes of ventricular repolarization?
Acute use of tobacco cigarettes or nicotine-containing electronic cigarettes prolongs ECG indexes of ventricular repolarization, which may be associated with increased sudden death risk.
May warrant caution with acute nicotine exposure; leaves open arrhythmia risk with chronic use.
Abnormal ventricular repolarization, as indicated by prolonged Tpeak-end (Tp-e), is associated with increased sudden death risk. Baseline ECG indexes of repolarization, Tp-e, Tp-e/QT, and Tp-e/QTc, were not different among tobacco cigarette (TC) smokers, electronic cigarette (EC) users, and nonsmokers at baseline, but when TC smokers smoked one TC, all parameters were prolonged. Using an electronic cigarette with nicotine, but not without nicotine, increased the Tp-e/QT. Smoking induces changes in ECG indexes of ventricular repolarization associated with increased sudden death risk.
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Ip et al. (2020) studied this question.
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