Population
Detergent-extracted fiber bundles isolated from mouse left ventricular papillary muscles
Comparison
Constitutively active form of ROCK-II vs Native (unphosphorylated) state
Design
Preclinical
Authors
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May depress myofilament function in cardiac disease; leaves open therapeutic targeting in humans.
ROCK-II phosphorylation of the troponin complex, specifically at cTnT, plays an important role in depressing cardiac myofilament tension and ATPase activity.
Vahebi et al. (2005) studied this question.
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