Reduction of Stroke Events With Pravastatin
Why the study?
Does pravastatin 40 mg/d reduce stroke events in patients with coronary disease or hypercholesterolemia compared to placebo?
Population
19,768 patients pooled from 3 large trials, including patients with documented coronary disease and…
Comparison
Pravastatin 40 mg/d vs Placebo
Design
Meta-analysis, randomized, placebo-controlled
Follow-up
approximately 5 years
Authors
Discussion
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Member takes
Implication
Supports pravastatin for stroke prevention in coronary disease; confirms benefit suggested by recent statin trials.
Structured PICO
Does pravastatin 40 mg/d reduce stroke events in patients with coronary disease or hypercholesterolemia compared to placebo?
P
Population
19,768 patients pooled from 3 large trials (CARE, LIPID, WOSCOPS), including patients with documented coronary disease (n=13,173) and hypercholesterolemic men.
I
Intervention
Pravastatin 40 mg/d
C
Comparator
Placebo
O
Outcome
Total stroke events over approximately 5 years of follow-uphard clinical
Pravastatin 40 mg/d significantly reduces the risk of total and nonfatal nonhemorrhagic strokes in patients with documented coronary disease.
Cite This Study
Byington et al. (2001) studied this question.