Thrombin and Platelets in Pulmonary Hypertension: A Lot More Than Clot

This article is intended to deliver a clinically relevant overview about the role of coagulation factors and platelets in the pathogenesis of pulmonary hypertension. After summarizing the available data with warfarin, some information is provided about the novel oral anticoagulants that were recently approved for atrial fibrillation and may soon be approved for venous thrombosis. The author is hopeful that this information will stimulate investigator interest in this topic and drive us toward meaningful studies about this important aspect of PAH therapy.