Key result
Thrombosis and endothelial dysfunction play a significant role in severe pulmonary hypertension, though it is unknown if they are the primary disturbance or a result of previous vascular injury.
Population
Patients with severe pulmonary hypertension (primary and secondary)
Design
Review
Authors
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Supports investigation of antithrombotic strategies in severe pulmonary hypertension; leaves open primary versus secondary role of thrombosis.
This review highlights the critical role of thrombosis and endothelial dysfunction in the pathophysiology of severe pulmonary hypertension, supporting the rationale for antithrombotic therapies.
Chaouat et al. (1996) conducted a review in Severe pulmonary hypertension. Thrombosis was evaluated. Thrombosis and endothelial dysfunction play a significant role in severe pulmonary hypertension, though it is unknown if they are the primary disturbance or a result of previous vascular injury.
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