Candida at Boston City Hospital

In a four-month period, 371 isolates ofCandida(C albicans, 68%;C tropicalis, 31%) were identified at Boston City Hospital. Sputum, urine, and wounds were the most frequent sources, in that order. Inocula replicating tests for susceptibility to eight antimicrobials showed that hamycin and amphotericin B were the most active; nystatin, kalafungin and endomycin ranked next; flucytosine (5-fluorocytosine) was slightly active and lomofungin and rifampin were inactive. Review of clinical records of 41 patients with apparentCandidainfection revealed a high incidence of multiple chronic diseases and high fatality rates. Acquisition ofCandidawas associated with prolonged hospitalization and antibiotic therapy, candiduria with indwelling urinary catheters, and candidemia with intravenous catheters. There was only one case of systemic candidiasis. Specific therapy is rarely required for apparentCandidainfection in hospitalized patients.