Why the study?
Does ET(A) receptor antagonism with LU135252 prevent obesity-induced tissue-specific activation of renal ACE and enhanced vascular contractility in C57BL/6J mice?
Does ET(A) receptor antagonism with LU135252 prevent obesity-induced tissue-specific activation of renal ACE and enhanced vascular contractility in C57BL/6J mice?
Obesity induces tissue-specific activation of renal ACE and enhances vascular contractility to angiotensin II in mice, effects that are prevented by ET(A) receptor antagonism.
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ET(A) antagonism prevented obesity-induced renal ACE activation and vascular changes in mice; hypothesis-generating, should not yet change practice.
Barton et al. (2000) studied this question.
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