What does this research mean for the field?

Coadministration of adrenomedullin and an endopeptidase inhibitor provides greater beneficial hemodynamic and renal effects in heart failure than either agent administered alone. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2002HypertensionOpen Access

Combined Endopeptidase Inhibition and Adrenomedullin in Sheep With Experimental Heart Failure

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Why the study?

Does the combination of adrenomedullin and an endopeptidase inhibitor improve hemodynamic and renal parameters in sheep with experimental heart failure?

Structured PICO

Does the combination of adrenomedullin and an endopeptidase inhibitor improve hemodynamic and renal parameters in sheep with experimental heart failure?

Population

8 sheep with experimental heart failure

Intervention

Adrenomedullin (50 ng/kg per minute infusion for 3 hours) and endopeptidase inhibitor SCH32615 (5 mg bolus + 1 mg/kg per hour infusion for 3 hours) administered separately and in combination

Comparator

Control condition

Outcome

Hemodynamic variables (arterial pressure, left atrial pressure, peripheral resistance, cardiac output) and renal function (urinary volume, sodium excretion, creatinine clearance)surrogate

Cotreatment with adrenomedullin and an endopeptidase inhibitor provides synergistic hemodynamic and renal benefits in an experimental sheep model of heart failure.

Discussion

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Implication

Premature for clinical use in heart failure; extends synergistic benefits of adrenomedullin-endopeptidase inhibition to experimental models.

Cite This Study

Rademaker et al. (2002) studied this question.

synapsesocial.com/papers/6a1bd1876f692abb725eea2c https://doi.org/10.1161/hy0102.099197

Topics

Heart failure HFrEF treatment

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Implication

Premature for clinical use in heart failure; extends synergistic benefits of adrenomedullin-endopeptidase inhibition to experimental models.

Combined Endopeptidase Inhibition and Adrenomedullin in Sheep With Experimental Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Topics

Combined Endopeptidase Inhibition and Adrenomedullin in Sheep With Experimental Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider