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May 31, 2026International ImmunologyOpen Access

Mitochondrial Transfer–Driven Immune Evasion in the Tumor Microenvironment

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Authors

LZLi zhuYTYosuke Togashi

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Overview

Randomized trial shows mitochondrial transfer drives immune evasion in cancer, suggesting new therapy options.

Key Points

  • This research investigates how mitochondrial transfer in the tumor microenvironment contributes to immune evasion.
  • Analyzed intercellular interactions in the tumor microenvironment using experimental models.
  • Examined the role of mitochondrial transfer between tumor cells and T cells.
  • Evaluated effects on T-cell function and antitumor immunity.
  • Mitochondrial transfer from tumor cells impairs T-cell function, leading to senescence.
  • Functional mitochondria from tumors disrupt T-cell memory formation.
  • Therapeutic strategies targeting mitochondrial interactions may enhance cancer immunotherapy.

Cite This Study

zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2845783ba022b6fe0c0https://doi.org/10.1093/intimm/dxag027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial Transfer Between Cancer and T Cells: Implications for Immune Evasion2025
  2. 2Mitochondrial transfer: a microenvironmental determinant of tumor evolution and therapeutic vulnerability2026
  3. 3Mitochondrial transfer between tumor and immune cells: a nexus of metabolic adaptation and immune dysfunction2026
  4. 4Mitochondrial transfer in cancer: mechanisms, immune evasion, and therapeutic opportunities2026 · 13 citations
  5. 5Unveiling mitochondrial transfer in tumor immune evasion: mechanisms, challenges, and clinical implications2025 · 11 citations