Review synthesizes mechanisms of mitochondrial transfer impacting tumor progression and immune response in cancer environments, suggesting new therapeutic targets.
Key Points
This review aims to synthesize evidence supporting the role of mitochondrial transfer in tumor and immune cell interactions, focusing on metabolic adaptation and immune dysfunction.
Analysis of current evidence regarding intercellular mitochondrial transfer mechanisms and effects on tumor and immune cell states.
Discussion of molecular networks involved in mitochondrial exchange including tunneling nanotubes and extracellular vesicles.
Evaluation of therapeutic strategies to disrupt mitochondrial trafficking and reprogram TME metabolism.
Mitochondrial transfer enhances tumor cell bioenergetic fitness and resistance to therapy.
Immune cells receive dysfunctional mitochondria, leading to immune suppression and reduced anti-tumor responses.
Identified molecular networks provide insights into potential therapeutic interventions targeting mitochondrial dynamics.