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February 17, 2020Journal of Cardiovascular Electrophysiology

The 2-year incidence of AT/AF diagnosis was significantly higher in the ICD DX group compared to the ICD VR group (11.4% vs 3.6%; adjusted HR 3.85, 95% CI 1.58-9.41, P = .003).

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Why the study?

Atrial tachycardia/fibrillation episodes are common in ICD recipients and can be undetected by standard single-chamber devices, prompting investigation into whether a single-lead ICD with an atrial dipole improves AT/AF diagnosis and management.

Does a single-lead ICD with an atrial dipole improve the diagnosis of new-onset atrial arrhythmias compared to a standard single-chamber ICD in patients without a history of atrial arrhythmias?

Comparison

Single-lead ICD with an atrial dipole (ICD DX) vs standard ICD (ICD VR)

Design

Registry-based cohort study

Follow-up

Median 27 months

Authors

Mauro Biffi
Mauro BiffiElectrophysiology
MIMatteo IoriSanta Maria Nuova HospitalEMElia De MariaIstituto Ramazzini

Discussion

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Overview

May increase new atrial arrhythmia detection with dipole single-lead ICDs without raising anticoagulation starts; leaves open effects on outcomes.

Structured PICO

Does a single-lead ICD with an atrial dipole improve the diagnosis of new-onset atrial arrhythmias compared to a standard single-chamber ICD in patients without a history of atrial arrhythmias?

P
Population
376 patients without a history of atrial tachycardia/fibrillation (AT/AF) implanted with an implantable cardioverter-defibrillator (ICD) for standard indications from the THINGS registry.
I
Intervention
Single-lead ICD with an atrial dipole (ICD DX)
C
Comparator
Standard single-chamber ICD (ICD VR)
O
Outcome
Diagnosis of new-onset atrial tachycardia/fibrillation (AT/AF)

In patients receiving a single-chamber ICD, a device with an atrial dipole significantly increased the detection of new-onset atrial arrhythmias compared to a standard device, though it did not significantly increase the initiation of oral anticoagulation.

Cite This Study

Biffi et al. (2020) studied this question.

synapsesocial.com/papers/6a1bd37cea84844e355f095ehttps://doi.org/10.1111/jce.14396
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subclinical atrial fibrillation detection with a floating atrial sensing dipole in single lead implantable cardioverter‐defibrillator systems: Results of the SENSE trial2019 · 34 citations
  2. 2Ability to remotely monitor atrial high-rate episodes using a single-chamber implantable cardioverter-defibrillator with a floating atrial sensing dipole2023 · 13 citations
  3. 3Clinical Experience with Tiered Atrial Therapies and Atrial Arrhythmia Prevention Algorithms in a Dual Chamber Cardioverter Defibrillator2006 · 5 citations
  4. 4Comparison of a Novel, Single-Lead Atrial Sensing System With a Dual-Chamber Implantable Cardioverter-Defibrillator System in Patients Without Antibradycardia Pacing Indications2010 · 56 citations
  5. 5The utilization of atrial sensing dipole in single lead implantable cardioverter defibrillator for detection of new‐onset atrial high‐rate episodes or subclinical atrial fibrillation: A systematic review and meta‐analysis2022 · 5 citations