What does this research mean for the field?

Phenylephrine-induced changes in autonomic tone increase left atrial refractoriness and intra-atrial conduction delay, and these non-uniform changes in refractoriness can precipitate atrial fibrillation in susceptible individuals. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

August 1, 1997HeartOpen Access

Effect of phenylephrine infusion on atrial electrophysiological properties.

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Why the study?

Does phenylephrine infusion alter atrial electrophysiological properties and induce atrial fibrillation in patients undergoing electrophysiological study?

Population

20 patients, aged 53 years, undergoing electrophysiological study for investigation of idiopathic paroxysmal…

Comparison

Constant phenylephrine infusion (mean dose 69… vs Baseline measurements before phenylephrine…

Design

Cohort

Authors

JLJim LeitchJohn Hunter Hospital MBM. BastaDalhousie University PFP. FletcherCancer Research UK Clinical Trials Unit

Discussion

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Implication

Phenylephrine-associated atrial changes support autonomic AF triggers; hypothesis-generating and should not yet change practice.

Structured PICO

Does phenylephrine infusion alter atrial electrophysiological properties and induce atrial fibrillation in patients undergoing electrophysiological study?

Population

20 patients, aged 53 (SD 6) years, undergoing electrophysiological study for investigation of idiopathic paroxysmal atrial fibrillation (n=7) or for routine follow up after successful catheter ablation of supraventricular tachycardia (n=13).

Intervention

Constant phenylephrine infusion (mean dose 69 (SD 18) mg/min) designed to increase sinus cycle length by 25%.

Comparator

Baseline measurements before phenylephrine infusion.

Outcome

Changes in left and right atrial effective refractory periods, atrial activation times, and frequency of induction of atrial fibrillation.surrogate

Phenylephrine infusion increases left atrial refractoriness and intra-atrial conduction delay, supporting the concept that changes in autonomic tone may precipitate atrial fibrillation in susceptible individuals.

Cite This Study

Leitch et al. (1997) studied this question.

synapsesocial.com/papers/6a1bd4b71567d2fc4d5f1993 https://doi.org/10.1136/hrt.78.2.166

Topics

Atrial fibrillation Persistent AF management

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Effect of phenylephrine infusion on atrial electrophysiological properties.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effect of phenylephrine infusion on atrial electrophysiological properties.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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