New-generation atrial antitachycardia pacing (Reactive ATP) is associated with reduced risk of persistent or permanent atrial fibrillation in patients with bradycardia: Results from the MINERVA randomized multicenter international trial
Why the study?
Does atrial preventive and antitachycardia pacing combined with managed ventricular pacing reduce the risk of persistent or permanent atrial fibrillation in patients with bradycardia and previous atrial tachyarrhythmias?
Population
1,166 patients with bradycardia, dual-chamber pacemaker, and previous atrial tachyarrhythmias, multinational.
Comparison
Atrial preventive pacing and atrial… vs Standard dual-chamber pacing or managed…
Design
RCT, Randomly assigned to DDDR, MVP, or DDDRP+MVP group
Follow-up
2 years
Authors
Discussion
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Member takes
Implication
Supports combined DDDRP+MVP pacing in bradycardia patients with prior AT; extends randomized evidence for device-based AF prevention.
Structured PICO
Does atrial preventive and antitachycardia pacing combined with managed ventricular pacing reduce the risk of persistent or permanent atrial fibrillation in patients with bradycardia and previous atrial tachyarrhythmias?
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Population
1,166 patients with bradycardia, dual-chamber pacemaker, and previous atrial tachyarrhythmias, multinational.
I
Intervention
Atrial preventive pacing and atrial antitachycardia pacing (DDDRP) in combination with managed ventricular pacing (MVP)
C
Comparator
Standard dual-chamber pacing (DDDR) or managed ventricular pacing (MVP) alone
O
Outcome
Incidence of permanent AF or persistent AF (≥7 consecutive days with AF) at 2 yearscomposite
In patients with bradycardia and previous atrial tachyarrhythmias, atrial preventive and antitachycardia pacing combined with managed ventricular pacing significantly reduces the progression to persistent or permanent atrial fibrillation compared to standard dual-chamber pacing.
Cite This Study
Padeletti et al. (2015) studied this question.