Impact of anti-tachycardia pacing on atrial fibrillation burden when added on top of preventive pacing algorithms: results of the prevention or termination (POT) trial
Key result
Adding ATP to preventive pacing algorithms fails to further reduce AF burden versus algorithms alone.
- n=85
Why the study?
The efficacy of preventive pacing algorithms and anti-tachycardia pacing in reducing atrial fibrillation burden remains controversial.
Does adding anti-tachycardia pacing to preventive pacing algorithms reduce atrial fibrillation burden in patients with pacing indications and documented atrial fibrillation?
Population
85 patients with pacing indication and documented AF >30 min/week
Comparison
Preventive pacing algorithms alone vs preventive pacing algorithms plus anti-tachycardia pacing
Design
Randomized crossover trial
Follow-up
3 months per treatment period
Authors
Discussion
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Member takes
Implication
Omitting anti-tachycardia pacing does not compromise AF control in pacemaker patients; confirms preventive pacing alone suffices and supports simplified programming.
Study Design
Type
RCT (n=85)
Randomization
randomized
Structured PICO
Does adding anti-tachycardia pacing to preventive pacing algorithms reduce atrial fibrillation burden in patients with pacing indications and documented atrial fibrillation?
P
Population
85 patients (mean age 68, 39% female) with pacing indications and >30 min/week of atrial fibrillation, randomized to preventive pacing algorithms with or without anti-tachycardia pacing.
I
Intervention
Preventive pacing algorithms (PPA) plus anti-tachycardia pacing (ATP) for 3 months
C
Comparator
Preventive pacing algorithms (PPA) alone for 3 months
O
Outcome
Atrial fibrillation (AF) burden at 3 monthssurrogate
Main Result
Absolute Event Rate: 81% vs 64%
Adding anti-tachycardia pacing to preventive pacing algorithms does not further reduce atrial fibrillation burden in patients with pacemakers.
Cite This Study
Mont et al. (2007) conducted an RCT in Atrial fibrillation (n=85). Preventive pacing algorithms (PPA) + anti-tachycardia pacing (ATP) vs. Preventive pacing algorithms (PPA) alone was evaluated on Atrial fibrillation burden. Adding anti-tachycardia pacing to preventive pacing algorithms did not further decrease atrial fibrillation burden compared to preventive pacing alone (81% vs 64% decrease).