The study demonstrates that chicken embryo fibroblasts and NIH 3T3 mouse cells can be transformed by DNAs from cells infected with specific avian viruses, with differing requirements for helper viruses.
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Supports DNA-mediated transformation by avian retroviruses in vitro; leaves open specific sequences and in vivo relevance.
Chicken embryo fibroblasts and NIH 3T3 mouse cells were transformable by DNAs of chicken cells infected with avian myelocytomatosis virus strain MC29 or with avian erythroblastosis virus. Transfection of chicken cells appeared to require replication of MC29 or avian erythroblastosis virus in the presence of a nontransforming helper virus. In contrast, NIH 3T3 cells transformed by MC29 or avian erythroblastosis virus DNA contained only replication-defective transforming virus genomes.
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Copeland et al. (1980) studied this question.
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