A simple computational model successfully replicates Guyton's classic experiments on venous return and circulatory filling pressure, providing a foundation for more complex cardiovascular modeling.
A computer model of the human cardiovascular system has been created based on Guyton's closed circuit analysis of the heart and the peripheral circulatory system. This model was checked against Guyton's experiments performed in anesthetised dogs regarding the normal venous return curve, the effect of mean circulatory filling pressure (MCFP) and the importance of arterial venous and capillary resistance. These comparisons indicate that this simple model is valid for the study of Guyton's experimental work and also forms the bases of a more complex model of the cardiovascular model with specific attention to the venous system.
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Zervides et al. (2005) studied this question.
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