Confounding and indication for treatment in evaluation of drug treatment for hypertension
Population
Hypertensive patients
Comparison
Drug treatment for hypertension vs Untreated patients
Design
Review
Authors
Discussion
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Member takes
Implication
May warrant caution interpreting observational J-curve risks in hypertension; challenges prior reports and leaves optimal targets unresolved.
Structured PICO
P
Population
Hypertensive patients
I
Intervention
Drug treatment for hypertension
C
Comparator
Untreated patients
O
Outcome
Validity of non-randomised comparisons of treatment effects
Highlights that confounding by indication must be carefully considered in non-randomised studies of hypertension treatment, as apparent harms of low blood pressure may reflect underlying severe atherosclerosis.
Cite This Study
Grobbee et al. (1997) studied this question.